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Pioneering translational in vivo imaging - from research to medicine
With results from genomics and proteomics enhancing our knowledge of the biochemical pathways involved in disease and revealing potential therapeutic targets, there is a growing opportunity to research, understand and measure underlying biological mechanisms and therapeutic responses in vivo.
By developing a unique portfolio of fluorescence-based agents and system solutions that enable scientists to, non-invasively, visualize and quantify biological mechanisms and therapeutic responses deep within the body at the molecular level, VisEn is pioneering a new era of in vivo imaging.
VisEn’s biocompatible fluorescence agents and the company’s breakthrough FMT technology platform for enabling fluorescence-based Quantitative Tomography are already facilitating data generation and translation from profiling to preclinical research and, ultimately, through into clinical trials and medical practice. Today, these powerful imaging solutions are contributing to a deeper understanding of biological mechanisms and therapeutic responses in areas such as inflammatory, cardiovascular, skeletal and pulmonary disease as well as oncology.
Disease
Oncology
Application examples
Evaluate disease progression and therapeutic response in tumor models
Study blood vessel density and angiogenesis in tumor models
Assess metastases in tumor models over time
Cardiovascular
Application examples
Image matrix metalloproteinase (MMP) activity after myocardial infarction
Image proteolytic activity and micro-calcification in models of atherosclerosis
Skeletal and Inflammatory
Application examples
Evaluate disease progression and therapeutic response in inflammatory disease
Characterize vascular changes and therapeutic response in arthritis models
Characterize bone remodeling in osteoporosis
Measure hormone-induced bone growth and steroid-induced bone resorption
Pulmonary
Application examples
Visually discriminate, measure and quantify disease severity and therapeutic response in asthma models
User-defined in vivo imaging
Application examples
Reporting and labeling using agents designed by the user

The vision to drive science – translation through to the clinic
While VisEn’s first commercial products are intended for in vivo imaging in disease models of small animals used in research and pre-clinical studies, all developments within the company are focused towards developing translational data, and translational solutions.
Close links with leading research, pharmaceutical and clinical institutions guide all VisEn developments, maintaining a focus towards a future of improved clinical disease understanding and treatment.

Development Partnerships - Expertise for customized solutions
VisEn has a broad range of competencies in developing fluorescence agents and in vivo imaging applications — turning initial concepts into validated products and applications. With a tradition of in vivo technology development and fully functional chemistry, biology and animal imaging capabilities, VisEn can work with partners on specific product and application development programs, tailored to their specific research areas. Contact for more information.