FMT 2500™ and Multi-Modality Imaging

VisEn has simplified multi-modality imaging by allowing for the rapid and easy implementation of imaging mice in the FMT 2500, easily transferring animals to CT, MRI, PET and Spect instruments and then quickly co-registering and fusing data sets. The result is the combination of powerful anatomical and functional insights in one data set.

Why Perform Multi-Modality Imaging with the FMT?

			Combine molecular/functional and anatomical data (FMT + CT / MRI / SPECT / PET)

			One modality does not answer all biological questions

			Leverage core facility instrumentation and investments to gather more robust biological insights across a broad range of applications

			Combine the different benefits/attributes of different modalities to gather the most insightful read-outs

			Gather multi-variant, multiplexed insights

Multi-Modality FMT – CT Imaging: Quantification of Tumor Vascularity & Cathepsin Activity in Lung Carcinoma

The image sequence show the quantification of the following VisEn Imaging agents via FMT and fused with CT-data:
			AngioSense® (Tumor vascularity)
			ProSense ® (Cathepsin activity)

Quantification of Tumor Vascularity & Cathepsin Activity in Lung Carcinoma

Sequence courtesy of Weissleder, R.,
Harvard/Mass General; Nature 2008;452:580-589

Multi-Modality FMT – CT Imaging: Quantification of MMP Activity in Inflamed Mouse Lungs

FMT Quantification of MMP activity in whole lungs of mice

Sequence courtesy of Dr. Mikael Pittet., Harvard/Mass General, Journal of Clinical Investigation: 2008: I36335,

Combined MRI and FMT in Mouse Brain: Glioma Response to Chemotherapy

MRI

MRI-FMT fusion image

J. Chen, JCI, 2009: “Combined magnetic resonance and fluorescence imaging
of the living mouse brain reveals glioma response to chemotherapy”

Easy animal handling between modalities

			Animals immobilized safely in the FMT Imaging Cassette

			Anesthetized animals can be easily and safely moved between the FMT and other instruments without movement or perturbation

			Fiducial markers allow for easy alignment and eventual image fusion between modalities

			Dedicated VisEn multi-modality adaptors available for for MRI, CT, Spect and PET

FMT Animal Cassette (with fiducial markers)

Animal Cassette inside Multi-Modality Adaptor

Easy Data Export and Image Fusion

			DICOM export of FMT data

			Simple co-registration (via fiducial markers) with data sets from other modalities

			Ability to use multitude of image analysis packages for fusion and analysis

Quantitative FMT molecular data co-registered with anatomical CT data

Cathepsin B activity is quantifies with VisEn’s ProSense fluorescent agent

Cathepsin B activity is quantified with VisEn's ProSense fluorescent agent

Image courtesy of Dr. Ralph Weissleder, Massachusetts General Hospital, 2008

The following multi-modality adaptor models are available from VisEn Medical:

Product

Order Code

FMT 2500™ - Bruker MR Multi-Modality Imaging Adapter

10536

FMT 2500™ - Gamma Medica PET/CT Multi-Modality Imaging Adapter

10537

FMT 2500™ - GE CT Multi-Modality Imaging Adapter

10728

FMT 2500™ - Siemens Inveon PET/CT Multi-Modality Imaging Adapter

10538

FMT 2500™ Custom-Developed Multi-Modality Imaging Adapter

p.o.a.