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Vascular fluorescence agents
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These are distributed passively through blood vessels to enable imaging of vascularity, blood pooling in tumors and inflammation, and vascular leakage.
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Application examples
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Real-time imaging of the blood pool and vascularity associated with tumor mass (AngioSense) |
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Tumor imaging using FMT System and AngioSense
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Fluorescence microscopy reveals distribution of tumor cells (DAPI, blue) and AngioSense (red). Magnification x 100
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Image: Nude mouse implanted with PC3 human prostate cancer.
Investigation: After 15 days, mouse was injected with AngioSense (2 nmoles) and imaged 24 hours later by FMT System. Immediately after, tumor was excised, snap frozen and sectioned (5 µm).
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Intravital microscopy of vasculature (AngioSPARK 680) |
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Superbright imaging of blood vessels by IVM over 4-6 h
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Image: IVM of murine auricular vasculature using a BioRad In Vivo Confocal Microscope at time intervals shown after injection of AngioSPARK 680. Courtesy of Ralph Weissleder, MD, PhD, Center for Molecular Imaging, Massachusetts General Hospital, Harvard University
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Imaging subcutaneous and deep tissues (AngioSPARK 680) |
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Surface tumors and heart are discriminated using AngioSPARK 680 and FMT System
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Image: Reconstructed coronal slices at a depth of 0.5 mm to 8.5 mm.
Investigation: Subcutaneous HT-29 colorectal xenografts in nude mice. AngioSPARK 680 was injected and imaging performed after 24 hours. |
For additional information and application support, please contact us
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Detailed application notes for download:
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